Emergence in Klebsiella pneumoniae of a chromosome-encoded SHV beta-lactamase that compromises the efficacy of imipenem.
نویسندگان
چکیده
A Klebsiella pneumoniae isolate was identified that had reduced susceptibility to several expanded-spectrum cephalosporins and imipenem. That isolate produced a chromosome-encoded SHV-type beta-lactamase, SHV-38, that had an alanine to valine substitution in position Ambler 146 compared to beta-lactamase SHV-1. The kinetic parameters for purified beta-lactamases SHV-38 and SHV-1 showed that the hydrolytic spectrum of SHV-38 included only ceftazidime and imipenem. This report is the first example of an SHV-type beta-lactamase capable of hydrolyzing imipenem.
منابع مشابه
Emergence in Klebsiella pneumoniae of a Chromosome-Encoded SHV -Lactamase That Compromises the Efficacy of Imipenem
متن کامل
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 47 2 شماره
صفحات -
تاریخ انتشار 2003